Ultimate Southern Chicken Spaghetti Casserole Recipe You Need to Try

Southern Chicken Spaghetti Casserole is one of those dishes that instantly feels like a warm hug after a long day. Growing up in a small English town, casseroles weren’t exactly a staple at my family table, but since moving to sunny San Diego and becoming a mom, I’ve come to cherish these comforting, all-in-one meals. This casserole combines creamy, cheesy goodness with tender chicken and perfectly cooked spaghetti—a combination that’s both nostalgic and satisfying. It’s the kind of dish that brings everyone together, often around my kitchen table where my kids enthusiastically argue over who gets the last cheesy bite.

Why You’ll Love This Southern Chicken Spaghetti Casserole

This casserole is a delightful mix of creamy textures and savory flavors. What makes it stand out for me is how it balances comfort with simplicity—no fancy ingredients, just honest, hearty food that feels homemade. The shredded chicken absorbs the sauce beautifully, and the combination of cheeses adds that perfect gooeyness that kids and adults alike adore. Plus, it’s a fantastic way to use leftover chicken, which I often have on hand thanks to my habit of roasting chickens for Sunday dinners. The dish freezes well too, making it a lifesaver for busy weeknights when I want a wholesome meal without fuss.

Ingredients You’ll Need for This Southern Chicken Spaghetti Casserole

this RECIPE

The key to this dish lies in selecting the right ingredients—fresh, quality items elevate the casserole from ordinary to memorable. When I shop for this recipe, I always opt for free-range chicken if possible and a good-quality shredded cheese blend for the best melt. I also find that homemade chicken stock, or even a rich store-bought broth, adds depth to the sauce that canned soup just can’t match. If you’re looking to lighten it up, Greek yogurt can substitute some of the creaminess without sacrificing flavor.

• 3 cups cooked, shredded chicken (rotisserie works well)
• 8 ounces spaghetti, cooked al dente
• 1 cup shredded cheddar cheese
• 1 cup shredded mozzarella cheese
• 1 can (10.5 ounces) cream of mushroom soup (or homemade white sauce)
• 1/2 cup sour cream or Greek yogurt
• 1/2 cup chicken broth
• 1 small onion, finely chopped
• 2 cloves garlic, minced
• 1/2 teaspoon smoked paprika
• Salt and black pepper, to taste
• 2 tablespoons butter or olive oil
• Fresh parsley for garnish (optional)

Nutrition Facts

• Calories: Approximately 450 per serving
• Protein: 35g
• Fat: 18g
• Carbohydrates: 35g
• Fiber: 2g
• Sugar: 4g
• Sodium: 700mg

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Steps to Create Your Southern Chicken Spaghetti Casserole

1. Preheat your oven to 350°F (175°C). Lightly grease a 9×13 inch casserole dish.
2. In a large skillet, melt butter over medium heat. Add the chopped onion and sauté until translucent, about 5 minutes. Stir in minced garlic and cook for another minute until fragrant.
3. In a mixing bowl, combine the cream of mushroom soup, sour cream (or Greek yogurt), chicken broth, smoked paprika, salt, and pepper. Mix well until smooth.
4. Add the shredded chicken, cooked spaghetti, and half of the shredded cheeses to the sauce mixture. Fold gently to combine everything evenly.
5. Transfer the mixture to the prepared casserole dish. Sprinkle the remaining cheese evenly on top.
6. Bake uncovered for 25-30 minutes, or until the cheese is golden and bubbly. Keep an eye on it after 20 minutes to prevent over-browning.
7. Remove from oven and let it rest for 5 minutes before serving. Garnish with fresh parsley if desired.

Tips for Making the Best Southern Chicken Spaghetti Casserole

Getting this casserole just right is about layering flavors and textures carefully. Over the years, I’ve learned a few tricks that make this dish shine every time.

• Use freshly cooked spaghetti, but undercook it slightly since it will continue to cook in the oven and soak up the sauce.
• Don’t skip sautéing the onions and garlic—it adds a depth of flavor that makes the casserole taste homemade rather than canned.
• For a richer sauce, try making a simple béchamel (white sauce) from scratch instead of canned soup—this is a technique I picked up in restaurant kitchens that really elevates the dish.
• Shred leftover roast chicken finely to ensure every bite is flavorful and moist.
• Let the casserole rest after baking so the sauce thickens and the flavors meld.

With these tips, you’ll create a restaurant-quality dish every time. Learn more: related recipe Learn more: Irresistibly Creamy Pepperoncini Chicken Skillet Recipe You Need to Try

Serving Suggestions and Pairings

This Southern Chicken Spaghetti Casserole is wonderfully versatile, making it perfect for casual family dinners or even potluck gatherings. I often serve it with simple sides that balance the richness and add freshness to the plate.

• Pair with a crisp green salad dressed lightly with lemon vinaigrette for a bright contrast
• Serve alongside roasted or steamed green beans for a touch of crunch and color
• A chilled glass of Sauvignon Blanc or sparkling water with a twist of lime complements the creamy casserole beautifully
• In cooler months, a bowl of homemade tomato soup is a cozy, nostalgic pairing

Whenever I make this casserole, it often becomes the centerpiece of the meal—bringing everyone around the table to share stories, laughter, and, of course, seconds.

Storage and Reheating Tips

Proper storage is essential to keep this casserole tasting fresh and delicious, especially when you’re prepping meals ahead of time or dealing with leftovers.

• Store any leftovers in an airtight container in the refrigerator for up to 3 days.
• When reheating, add a splash of chicken broth or a little cream to loosen the sauce and maintain its creamy texture.
• Reheat gently on the stovetop over low heat or in the microwave in short bursts, stirring occasionally to prevent drying out or curdling.
• This casserole freezes well—wrap tightly and freeze for up to 2 months. Thaw overnight in the fridge before reheating.

Frequently Asked Questions

What are the main ingredients for Southern Chicken Spaghetti Casserole?

The main ingredients for Southern Chicken Spaghetti Casserole include the items listed in our ingredients section above. Each ingredient plays a crucial role in achieving the perfect flavor and texture.

How long does it take to make Southern Chicken Spaghetti Casserole?

The total time to make Southern Chicken Spaghetti Casserole includes both preparation and cooking time. Check the recipe card above for exact timing details.

Can I make Southern Chicken Spaghetti Casserole ahead of time?

Yes, Southern Chicken Spaghetti Casserole can often be prepared in advance. Store it properly in an airtight container in the refrigerator and consume within the recommended timeframe.

What can I serve with Southern Chicken Spaghetti Casserole?

Southern Chicken Spaghetti Casserole pairs well with various sides and accompaniments. Consider the serving suggestions mentioned in the recipe for the best dining experience.

Is Southern Chicken Spaghetti Casserole suitable for special diets?

Depending on the ingredients used, Southern Chicken Spaghetti Casserole may be adapted for various dietary needs. Check the ingredients list and consider substitutions as needed for your dietary requirements.

Final Thoughts

I hope this Southern Chicken Spaghetti Casserole brings as much comfort and joy to your table as it does to mine. It’s a dish rooted in simplicity but packed with flavor and warmth—the kind of meal that makes you feel at home, no matter where you are. I’d love to hear how your version turns out or any tweaks you make to suit your family’s tastes. Happy cooking, and welcome to my kitchen!